Evidence map›Paper›PMID 42485436›Full record

ArticleScience translational medicine2026

Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy in preclinical mouse models.

Mathieu Rouanne, Noah Chen, Dylan L Mariuzza, Zaofeng Yang, Fangda Li, Kenia de Los Santos-Alexis, Thomas M Savage, Rosa L Vincent, Cathy L Mendelsohn, Tal Danino and 1 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mathieu RouanneDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-2970-4821
Noah ChenDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-9795-4561
Dylan L MariuzzaDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-9369-2514
Zaofeng YangDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-4861-9729
Fangda LiDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-4697-3989
Kenia de Los Santos-AlexisDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-3628-9796
Thomas M SavageDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-6618-2973
Rosa L VincentDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.ORCID 0000-0003-0742-8977
Cathy L MendelsohnDepartment of Urology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-4026-4073
Tal DaninoHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-2713-7659
Nicholas ArpaiaDepartment of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0657-0528

Funding

Modulation of the tumor microenvironment with probiotic therapiesR01CA249160 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ARPAIA, NICHOLAS, DANINO, TAL · 2020 to 2024
$3.0M
Engineering immunotherapeutic probiotics to mitigate irAEU01CA247573 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ARPAIA, NICHOLAS, DANINO, TAL · 2020 to 2024
$2.9M
Treating colon cancer by regulating intestinal immunity through microbial metabolismR01CA259634 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPAIA, NICHOLAS · 2021 to 2025
$2.8M
NCI NIH HHS R01 CA249160NCI NIH HHS R01 CA259634NCI NIH HHS U01 CA247573
6 · The paper itself

Abstract

The intratumoral microbiome has recently emerged as a potential hallmark of cancer, with implications for response or resistance to therapy. Bacteria can either promote or inhibit cancer growth. However, intratumoral bacteria can also be engineered using synthetic biology to remodel the tumor microenvironment. Here, we engineered the probiotic bacterium

Indexed as

Antibodies, NeoplasmEscherichia coliImmunotherapyUrinary Bladder NeoplasmsAnimalsCell Line, TumorChemokine CXCL13Disease Models, AnimalFemaleHumansMiceMice, Inbred C57BLAntibodies, NeoplasmChemokine CXCL13

Identifiers

PMID42485436
PMCPMC13556988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.