Evidence map›Paper›PMID 42485421›Full record

ArticlePloS one2026

Association of triglyceride-glucose index (TyG) and a body shape index (ABSI) with cognitive decline and dementia risk.

Shuangshuang Yang, Lili Cui, Jinxin Zhang, Ying Yang, Junhao Huo, Yuyan Ding, Jingni Zhang, Shulan He, Jiangping Li

Abstract read
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In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shuangshuang YangDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Lili CuiDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Jinxin ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Ying YangDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Junhao HuoDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Yuyan DingDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Jingni ZhangDepartment of Science and Education, Qinghai Provincial People's Hospital, Xining, Qinghai, PR China.
Shulan HeDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Jiangping LiDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID https://orcid.org/0000-0001-5183-3713

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLongitudinal evidence linking the body shape index (ABSI) to dementia and its subtypes remains scarce. Furthermore, the use of ABSI and TyG-ABSI as predictors of cognitive decline and dementia is infrequent. Therefore, this study aimed to examine the relationships between the triglyceride-glucose (TyG) index, ABSI, and TyG-ABSI indices and their predictive value for cognitive decline and dementia risk.

methodsThis study included 370,744 participants from the UK Biobank. The TyG and ABSI indices were calculated using their respective formulas, while the TyG-ABSI index was derived by multiplying TyG and ABSI. Cognitive decline was defined as scoring in the bottom 25% on cognitive tests, while dementia was diagnosed from first-recorded incidents and algorithmically-defined outcomes. Logistic regressions were employed to assess the associations of TyG, ABSI and TyG-ABSI indices with cognitive decline; Cox regressions were used to analyze the associations of these indices with the risk of all-cause dementia (ACD) and its subtypes.

resultThe TyG, ABSI, and TyG-ABSI indices were all significantly associated with cognitive decline. Additionally, compared with the lowest quartiles, the highest quartiles of TyG, ABSI and TyG-ABSI indices were associated with a significantly increased risk of ACD by 33% (HR = 1.33, 95% CI: 1.13-1.57), 79% (HR = 1.79, 95% CI: 1.65-1.94) and 67% (HR = 1.67, 95% CI: 1.54-1.82), respectively. These indices were also significantly associated with the risk of Alzheimer's disease (AD) and vascular dementia (VD) (all P < 0.05).

conclusionThe TyG, ABSI, and TyG-ABSI indices are significantly and positively linked to the risk of cognitive decline and dementia.

Indexed as

Blood GlucoseCognitive DysfunctionDementiaTriglyceridesAgedFemaleHumansMaleRisk FactorsBlood GlucoseTriglycerides

Identifiers

PMID42485421
PMCPMC13390943

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