Trial reportPloS one2026
Understanding driver behaviour after consuming conventional wines with different sulphite contents: Insights from a driving simulator study.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlcohol consumption is a contributing factor to traffic crashes and road fatalities worldwide. While the effects of blood alcohol concentration (BAC) on driving performance are well documented, less is known about the role of sulphites, used for their antimicrobial and antioxidant properties, on driving performance.
methodUsing a triple-blind, randomised, within-subjects design, thirty-two participants completed three driving simulation trials under sober conditions and after consuming a conventional red wine with 'low' (86 mg/l) and 'high' (126 mg/l) sulphite content, while maintaining a BAC at about the Italian legal limit (0.5‰). The driving behaviour was assessed in rural, urban and rural-urban transition environments.
resultsIn less demanding rural environments, where participants drove in free-flow conditions (i.e., rural and transitional), only BAC affected lateral vehicle control along curves, increasing the standard deviation of lateral position relative to the sober baseline, but no significant differences emerged between the two sulphite levels. However, in the more demanding urban environment, when drivers consumed wine with higher sulphite content, they showed more cautious behaviour during sudden interactions with pedestrians at zebra crossings compared with the sober condition. Conversely, in a car following task, when they drank high-sulphite wine, they behaved more dangerously, maintaining higher speeds and shorter headways with respect to the baseline.
conclusionsWithin legal BAC limits, higher sulphite content in wine was associated with context-dependent changes in driving behaviour, promoting greater caution in complex urban scenarios but riskier behaviour in car-following tasks. The small number of significant effects supports the effectiveness of current legal limits, and the findings should be interpreted strictly within regulated conditions, while highlighting the need for further research on sulphite-related effects.
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