Evidence map›Paper›PMID 42485223›Full record

ArticleBioinformatics (Oxford, England)2026

Systematic analysis of CDR contacts and pairing constraints between T cell receptor αβ chains.

Martina Milighetti, Yuta Nagano, James Henderson, Uri Hershberg, Andreas Tiffeau-Mayer, Anne-Florence Bitbol, Benny Chain

Abstract read
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In one paragraph

Article in Bioinformatics (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Martina MilighettiDivision of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom.ORCID 0000-0003-4170-8796
Yuta NaganoDivision of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom.ORCID 0000-0002-1784-9276
James HendersonDivision of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom.
Uri HershbergDepartment of Human Biology, School of Life Sciences, Faculty of Sciences and Center of Biophysics and Quantitative Biology, University of Haifa, Haifa 3498858, Israel.
Andreas Tiffeau-MayerDivision of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom.ORCID 0000-0002-6643-7622
Anne-Florence BitbolInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.ORCID 0000-0003-1020-494X
Benny ChainDivision of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom.ORCID 0000-0002-7417-3970

Funding

Cancer Research UK City of London Centre BCCG1C8R
6 · The paper itself

Abstract

motivationThe six complementarity determining regions (CDRs) of the T cell receptor (TCR) form multiple contacts with cognate peptide and major histocompatibility complex, thus determining antigen specificity. However, the contacts between the CDRs themselves are less understood.

resultsOur systematic study of all available TCR crystallographic structures identified consistent patterns of intra- and inter-chain CDR contacts in both free and antigen-bound TCRs. In addition, the protein sequences of TCRα and TCRβ from sets of TCRs which recognise a shared antigen shared mutual information and were not independent. As a result, sequence-based models can partially predict TCRα/TCRβ pairing de novo. The conserved patterns of CDR amino acid contacts, and the mutual sequence constraints between antigen-specific sets of TCR α and β chains represent an under-appreciated element of TCR structure, which may play an important role in T cell antigen recognition. AVAILABILITY AND IMPLEMENTATION: The code and data necessary to reproduce the analyses are available at https://github.com/mm523/TCRab-pairing.

Indexed as

Complementarity Determining RegionsReceptors, Antigen, T-Cell, alpha-betaAmino Acid SequenceModels, MolecularComplementarity Determining RegionsReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID42485223
PMCPMC13447020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.