ReviewJournal of diabetes research2026
GDF15: A Novel Insight Into Its Biology and Therapeutic Potential in Obesity.
Review in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- GDF15: A Novel Insight Into Its Biology and Therapeutic Potential in Obesity.Journal of diabetes research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine that has recently been identified as a key regulator of appetite homeostasis. Although GDF15 was previously regarded as only a biomarker of disease burden, the discovery of its exclusive receptor, GFRAL, repositioned it as a key mediator of sickness-associated anorexia. The clinical significance of GDF15 and its receptor, GFRAL, is supported by evidence that established weight-loss agents influence circulating GDF15 levels and that GDF15 agonists induce marked weight loss in both preclinical and early-phase clinical studies. This review integrates recent advances in GDF15 biology from evolutionary, mechanistic and translational perspectives, with particular emphasis on its emerging therapeutic potential in obesity.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.