Evidence map›Paper›PMID 42485101›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026

Partially countering the physiological effects of fentanyl with naloxone or d-cysteine ethyl ester in adult goats.

Reiauna Taylor, Suzanne E Neumueller, John DeSalvo, Grace Hilbert, Ilya R Bederman, Stephen J Lewis, Lawrence G Pan, Hubert V Forster, Matthew R Hodges

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reiauna TaylorDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Suzanne E NeumuellerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
John DeSalvoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Grace HilbertDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Ilya R BedermanDepartment of Genetics and Genome Science, Case Western Reserve University, Cleveland, Ohio, United States.
Stephen J LewisDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-7050-0666
Lawrence G PanDepartment of Physical Therapy, Marquette University, Milwaukee, Wisconsin, United States.
Hubert V ForsterDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-6228-2942
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-1692-9055

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Reversing opioid-induced hypoxemia with novel thiol-based drugs without compromising analgesia in goatsRF1DA050571 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI FORSTER, HUBERT V, HODGES, MATTHEW ROBERT · 2022 to 2022
$2.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL007852HHS | NIH | National Institute on Drug Abuse (NIDA) DA050571NHLBI NIH HHS T32 HL007852NIDA NIH HHS RF1 DA050571
6 · The paper itself

Abstract

Fentanyl is the leading contributor to opioid-involved overdose (OD) mortality in the United States. Despite the demonstrated efficacy, safety, and wide availability of naloxone (NAL), opioid-involved OD fatalities remain high. This suggests our understanding of the negative integrated physiological effects of fentanyl remains incomplete, and highlights the need to develop additional novel countermeasures. Here we tested whether the physiological and behavioral effects of intravenous fentanyl in adult female goats (

Indexed as

Analgesics, OpioidCysteineFentanylNaloxoneAnimalsFemaleGoatsHypoventilationHypoxiaNarcotic AntagonistsRespirationAnalgesics, OpioidCysteineFentanylNaloxoneNarcotic AntagonistsbreathingfentanylnaloxoneOIRDwooden chest syndrome

Identifiers

PMID42485101
PMCPMC13507957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.