Evidence map›Paper›PMID 42485008›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Splenic B Cells Accumulate and Adopt a Pro-Inflammatory Phenotype to Accelerate Fibrosis in a CCl

Keping Feng, Qiaoman Fei, Chongyu Zhang, Junqiao Feng, Ke Du, Na Huang, Xurui Zhang, Zhe Zhou, Chengbo Zhang, Shaoying Zhang and 3 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Keping FengDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0003-4217-4343
Qiaoman FeiDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chongyu ZhangDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Junqiao FengDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ke DuDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Na HuangDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xurui ZhangDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zhe ZhouDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chengbo ZhangDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shaoying ZhangDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shemin LuShaanxi Provincial Clinical Medical Research Center for Liver and Spleen Diseases, CHESS-Shaanxi Consortium, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yanying DongDepartment of Transfusion Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Guangyao KongDepartment of General Surgery, National-Local Joint Engineering Research Center of Biodiagnostic & Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

MOST | National Natural Science Foundation of China (NSFC) 82003905MOST | National Natural Science Foundation of China (NSFC) 82471849
6 · The paper itself

Abstract

The spleen plays a significant role in hepatic fibrosis progression. B cells are the main splenic lymphocytes, but their specific contributions and underlying mechanisms remain unclear. Hepatic fibrosis was induced in mice by intraperitoneal administration of carbon tetrachloride (CCl

Indexed as

B-LymphocytesCarbon TetrachlorideInflammationLiver CirrhosisSpleenAnimalsDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLNF-kappa Bp38 Mitogen-Activated Protein KinasesPhenotypeSignal TransductionSplenectomyCarbon TetrachlorideNF-kappa Bp38 Mitogen-Activated Protein Kinaseshepatic fibrosisp38 MAPK/NF‐κB pathwaypro‐inflammatory phenotypespleen–liver axissplenic B cells

Identifiers

PMID42485008
PMCPMC13390712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.