Evidence map›Paper›PMID 42484983›Full record

ArticleDigestive diseases and sciences2026

Bile Acid Malabsorption Panel in Patients with Treated Neuroendocrine Tumors.

Ayah Matar, Thorvardur R Halfdanarson, Mohamad B Sonbol, Timothy J Hobday, Patrick W McGarrah, Morgan C Miller, Rachel A Eiring, Leslie J Donato, Michael Camilleri

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ayah MatarDivision of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, 200 First St. S.W, Charlton Building, Rm. 8-110, Rochester, MN, 55905, USA.
Thorvardur R HalfdanarsonDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Mohamad B SonbolDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Timothy J HobdayDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Patrick W McGarrahDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Morgan C MillerDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Rachel A EiringDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Leslie J DonatoDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Michael CamilleriDivision of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, 200 First St. S.W, Charlton Building, Rm. 8-110, Rochester, MN, 55905, USA. camilleri.michael@mayo.edu.ORCID http://orcid.org/0000-0001-6472-7514

Funding

NIH HHS R01-DK115950
6 · The paper itself

Abstract

purposePatients with neuroendocrine tumors experience diarrhea due to bioactive products of neuroendocrine tumors, bile acid malabsorption, or small bowel resection. We previously validated a bile acid malabsorption panel based on single stool primary bile acid (> 10%) and fasting serum C4 (> 52.5 ng/mL) to diagnose bile acid malabsorption.

methodsOur aim in this study was to audit diagnosis of bile acid malabsorption using the bile acid malabsorption panel in patients with treated neuroendocrine tumors compared with patients with functional diarrhea.

resultsBile acid malabsorption was identified in 14/23 (61%) patients with neuroendocrine tumors based on combined C4 and single stool primary bile acid. Bile acid malabsorption was more prevalent in patients with NET than in patients with functional diarrhea as demonstrated by significantly higher primary bile acids and serum C4.

conclusionThe bile acid malabsorption panel is a feasible convenient test to positively diagnose bile acid malabsorption in patients with neuroendocrine tumors.

Indexed as

Bile Acids and SaltsDiarrheaMalabsorption SyndromesNeuroendocrine TumorsSteatorrheaAdultAgedAged, 80 and overFecesFemaleHumansMaleMiddle AgedBile Acids and Salts7α-hydroxy-4-cholesten-3-oneCarcinoidDiarrheaStool

Identifiers

PMID42484983

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