Evidence map›Paper›PMID 42484715›Full record

ArticleLangenbeck's archives of surgery2026

Indocyanine green fluorescence kinetics during hypothermic oxygenated machine perfusion might predict graft function after liver transplantation.

Mareike Franz, Jörg Arend, Antonia Bollensdorf, Frederike Stelter, Ahmed Sanin, Thomas Wartmann, Ulf D Kahlert, Verena Keitel-Anselmino, Theresa Florian, Roland Croner

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Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Mareike FranzDepartment of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany. mareike.franz@med.ovgu.de.ORCID http://orcid.org/0000-0001-6258-3756
Jörg ArendDepartment of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Antonia BollensdorfDepartment of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Frederike StelterDepartment of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Ahmed SaninDepartment of Molecular & Experimental Surgery (MES), Department of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Thomas WartmannDepartment of Molecular & Experimental Surgery (MES), Department of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Ulf D KahlertDepartment of Molecular & Experimental Surgery (MES), Department of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Verena Keitel-AnselminoDepartment of gastroenterology, hepatology and infectiology, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Theresa FlorianDepartment of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.
Roland CronerDepartment of general-, visceral-, vascular- and transplant surgery, Leipiziger Str. 44, Magdeburg, 39120, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study evaluates whether indocyanine green (ICG) fluorescence during hypothermic oxygenated machine perfusion (HOPE) can predict early allograft dysfunction (EAD) after liver transplantation.

methodsSeventeen donor livers underwent HOPE before transplantation. After one hour, ICG was administered via the portal line. Perfusate samples were collected every five minutes for 50 min; liver tissue and bile samples were obtained during perfusion and after reperfusion. Fluorescence intensity (FI) was quantified using standardized microplate analysis. Associations with donor characteristics and clinical outcomes were analyzed.

resultsEAD occurred in 29.4% of recipients and primary non-function in 5.9%. Perfusate FI differed significantly between EAD and non-EAD grafts at 40 and 45 min (p = 0.006; p = 0.05). FI in post-reperfusion liver biopsies was higher in dysfunctional grafts (p = 0.01). Bile fluorescence showed no predictive value. ROC analysis demonstrated strong discrimination for perfusate samples at 40 and 45 min (AUC 0.875; 0.889) and for post-reperfusion tissue (AUC 0.886). Donor variables did not correlate with ICG kinetics.

conclusionIn this exploratory pilot study, perfusate fluorescence measurements during HOPE were associated with EAD. These findings suggest that fluorescence- based assessment during machine perfusion may provide functional information on graft quality.

Indexed as

Coloring AgentsHypothermia, InducedIndocyanine GreenLiver TransplantationPerfusionPrimary Graft DysfunctionAdultFemaleFluorescenceHumansMaleMiddle AgedOrgan PreservationPilot ProjectsPredictive Value of TestsColoring AgentsIndocyanine GreenDonor liver viabilityEarly graft dysfunction predictionExtended- criteria donor graftsGraft assessmentHepatocellular uptakeHepatocyte transporter functionHypothermic oxygenated perfusionMitochondrial stress indicatorsPerfusate fluorescence intensityPredictive threshold for graft failure

Identifiers

PMID42484715
PMCPMC13391663

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