ArticleJournal of materials science. Materials in medicine2026
Chitosan and chitosan-silver nanoparticles as adjuncts to platelet-rich plasma in canine full-thickness cutaneous wound healing.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Enhancing full-thickness cutaneous wound repair in dogs remains challenging, particularly when infection risk and delayed regeneration are expected. Platelet-rich plasma (PRP) delivers a concentrated pool of growth factors, while chitosan-based nanoparticles-especially silver-functionalized systems-may provide antimicrobial protection and support tissue remodeling. This study evaluated PRP alone or combined with chitosan nanoparticles (PRP/CS NPs) or chitosan-capped silver nanoparticles (PRP/CS/Ag NPs) in experimentally induced full-thickness skin wounds in dogs. Twenty-four healthy male mongrel dogs were randomized into four groups (n = 6): saline control, PRP, PRP/CS NPs, and PRP/CS/Ag NPs. Standardized 2 × 2 cm full-thickness wounds were created surgically and followed for 21 days using clinical wound assessment, wound area and contraction measurements, histopathology, collagen deposition analysis, and immunohistochemical staining for EGF and α-SMA. All treatments significantly reduced wound size and increased contraction versus controls over time (p < 0.001). PRP/CS/Ag NPs achieved the greatest wound size reduction, particularly on days 7, 14, and 21, with a significant difference from controls at day 14 (p < 0.001). PRP promoted higher early collagen deposition (day 7), whereas PRP/CS/Ag NPs induced sustained and significantly greater collagen deposition at days 14 and 21. Immunohistochemistry showed consistently higher EGF expression in the PRP/CS/Ag NPs group across time points, while PRP/CS NPs increased α-SMA expression, consistent with enhanced myofibroblast activity. PRP accelerates early wound repair, while chitosan-based nanoparticles modulate later healing events.PRP combined with PRP/CS/Ag NPs produced the most consistent improvement in wound closure, collagen remodeling, and epithelial regeneration, supporting silver-functionalized chitosan nanoparticles as a promising adjunct to PRP for managing full-thickness cutaneous wounds in dogs.
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