Evidence map›Paper›PMID 42484699›Full record

ArticleActa diabetologica2026

Improving cognition through lifestyle-induced remission of type 2 diabetes: findings from DIABEPIC-2.

Marie Ouellet, Christopher Gudas-Cantin, Valérie Dionne, Christine Gagnon, Mathieu Gayda, Florent Besnier, Élise Latour, Christos Badas, Sara Desmarais, Neus Camins-Vila and 3 more

Abstract read
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In one paragraph

Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marie OuelletResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.ORCID http://orcid.org/0009-0007-1888-8190
Christopher Gudas-CantinResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Valérie DionneResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Christine GagnonResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Mathieu GaydaResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Florent BesnierResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Élise LatourResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Christos BadasResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Sara DesmaraisResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Neus Camins-VilaInstitut Nacional d'Educació Física de Catalunya (INEFC), Universitat de Barcelona (UB), Barcelona, Spain.
Louis BhererResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Josep Iglesies-GrauResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
Tanya MailhotResearch Center and Centre ÉPIC, Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada. t.mailhot@umontreal.ca.ORCID http://orcid.org/0000-0002-3156-4955

Funding

Fonds de Recherche du Québec - Santé 374043Universitat de Barcelona CEX2021-001159-M
6 · The paper itself

Abstract

aimsCognitive deficits are common but underrecognized complications of type 2 diabetes (T2D), which may be mitigated by lifestyle factors. The DIABEPIC-2 pilot trial evaluated a 6-month lifestyle intervention targeting T2D remission. We aimed to assess post-intervention changes in cognitive performance and identify associations with metabolic, anthropometric and intervention-related parameters.

methods. This secondary analysis included thirty adults with T2D (mean age 63.0 years, 60% male) who completed neuropsychological testing before and after an intervention combining nutritional counseling and supervised exercise. Cognitive outcomes were analyzed using repeated-measures ANOVAs, and indicators were calculated to identify clinically meaningful changes. Associations with hemoglobin A1c (HbA1c), relative fat mass (RFM), exercise dose, dietary adherence and remission status were examined using multivariable or logistic regression models.

resultsSignificant improvements were observed in global cognition (p = 0.03), verbal memory (p = 0.008), and executive function (p = 0.005). Clinically meaningful memory improvements occurred in 20% of participants. Reductions in HbA1c and RFM, as well as higher exercise dose, were independently associated with greater memory gains, whereas dietary adherence and remission status were not.

conclusion. A lifestyle intervention for T2D remission was associated with improvements in global cognition and executive function, as well as clinically meaningful gains in verbal memory. These benefits appear primarily driven by improvements in glycemic control, body composition, and exercise engagement rather than remission itself. Larger controlled trials are warranted to confirm these findings and document long-term cognitive effects.

Indexed as

Cognitive functionDiabetesExerciseLifestyleNutritionRemission

Identifiers

PMID42484699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.