Evidence map›Paper›PMID 42484635›Full record

ReviewZeitschrift fur Gerontologie und Geriatrie2026

[Misdirected intercellular communication in aging and chronic inflammation].

Anne Großkopf, Lars Saemann, Andreas Simm

Abstract readEnglish AbstractReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Zeitschrift fur Gerontologie und Geriatrie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anne GroßkopfKlinik für Herzchirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle (Saale), Deutschland.
Lars SaemannKlinik für Herzchirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle (Saale), Deutschland.
Andreas SimmKlinik für Herzchirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle (Saale), Deutschland. andreas.simm@uk-halle.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intercellular communication refers to the various ways through which cells communicate with one another and exchange a wide range of messages. Aging leads to a shift from coordinated signal transmission to disrupted, uncoordinated communication, which is primarily caused by senescent cells and their secretome (senescence-associated secretory phenotype, SASP). This breakdown drives systemic aging and leads to dysfunction and inflammatory processes throughout the body. A translational approach now involves either reducing the number of senescent cells using senolytics or inhibiting their SASP using senomorphics. This approach, which has been successful in animal studies, is now to be translated to humans.

Indexed as

AgingCell CommunicationCellular SenescenceInflammationSenotherapeuticsAnimalsChronic DiseaseHumansSenescence-Associated Secretory PhenotypeSignal TransductionSenotherapeuticsCellular senescenceGeroscienceSecretory phenotypeSenotherapeutic agentsSignal transduction

Identifiers

PMID42484635
PMCPMC13433382

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.