Evidence map›Paper›PMID 42484324›Full record

ArticlemBio2026

Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis.

M Ding, J Drnevich, J M Yoder, E V Dang, K Nielsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

M DingDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-7497-8157
J DrnevichRoy J. Carver Biotechnology Center, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-1401-8311
J M YoderDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
E V DangNIAID Laboratory of Host Immunity and Microbiome, Rockville, Maryland, USA.ORCID 0000-0002-2389-6167
K NielsenDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-2318-168X

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
Impact of Cryptococcus Titan Cells on Pathogenesis.R01AI134636 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Kirsten Nielsen · 2018 to 2026
$4.6M
The adaptive host response to latent cryptococcosisF30AI155292 · NIAID · UNIVERSITY OF MINNESOTA · PI DING, MINNA · 2021 to 2025
$150k
NIAID NIH HHS F30 AI155292NIAID NIH HHS R01 AI134636NIGMS NIH HHS T32 GM008244NIH HHS F30AI155292NIH HHS R01AI134636NIH HHS R01NS412966NIH HHS T32GM008244University of Minnesota Lung Biology Dinnaken Fellowship
6 · The paper itself

Abstract

IMPORTANCE: CD4 T cells are a critical part of the adaptive immune response in many infections. Upon inhalation of the fungal pathogen

Indexed as

CryptococcosisCryptococcus neoformansCTLA-4 AntigenLatent InfectionLymphocyte ActivationTh1 CellsAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleGATA3 Transcription FactorInterferon-gammaLungMiceMice, Inbred C57BLT-Box Domain ProteinsCTLA-4 AntigenGATA3 Transcription FactorInterferon-gammaT-Box Domain ProteinsAIDSCD4cryptococcosisCryptococcus neoformansgranulomatous immune responseimmuneimmune mechanismsT-cell activation

Identifiers

PMID42484324
PMCPMC13463883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.