Evidence map›Paper›PMID 42483856›Full record

ArticleInternational journal of urology : official journal of the Japanese Urological Association2026

Chronic Kidney Disease Frequently Observed in Adults With Spina Bifida.

Masaaki Imamura, Atsushi Hamano, Koji Yoshimura

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Article in International journal of urology : official journal of the Japanese Urological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Masaaki ImamuraDepartment of Urology, Shizuoka General Hospital, Shizuoka, Japan.ORCID https://orcid.org/0000-0002-0406-4058
Atsushi HamanoDepartment of Urology, Shizuoka General Hospital, Shizuoka, Japan.
Koji YoshimuraDepartment of Urology, Shizuoka General Hospital, Shizuoka, Japan.ORCID https://orcid.org/0000-0001-6342-7691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe evaluated the association between chronic kidney disease and the current and background conditions of adults with spina bifida.

methodsPatients with spina bifida (group A, n = 34) and patients with a history of pediatric encephalitis or spinal cord injury (group B, n = 23) who were older than 18 years between January 2013 and August 2022 were retrospectively analyzed. The chronic kidney disease-free survival was compared between groups. In each group, the congenital or pediatric background conditions (gender, disease type, history of febrile urinary tract infection, bladder augmentation, vesico-ureteral reflux, or detrusor overactivity) and current background conditions (age at last follow-up, ambulatory status, hypertension, and albuminuria) were compared between patients with or without chronic kidney disease.

resultsThe median age was 37 years (range 20-67 years). The median chronic kidney disease-free survival was younger in group A than group B (48.0 vs. 65.0 years, p = 0.0027). In group A, chronic kidney disease was associated with pediatric febrile urinary tract infection (p = 0.0018) and vesico-ureteral reflux (p = 0.0090), current hypertension (p < 0.001), and albuminuria (p = 0.0053). Multivariate analysis showed only hypertension was significantly associated with chronic kidney disease.

conclusionYoung to middle-aged adults with spina bifida with a history of pediatric febrile urinary tract infection or vesico-ureteral reflux and those with current hypertension or albuminuria have an increased risk of chronic kidney disease, suggesting the need for renal function monitoring.

Indexed as

Renal Insufficiency, ChronicSpinal DysraphismAdultAgedFemaleHumansHypertensionMaleMiddle AgedRetrospective StudiesRisk FactorsUrinary Tract InfectionsVesico-Ureteral RefluxYoung Adultadulthoodalbuminuriachronic kidney diseasehypertensionspina bifida

Identifiers

PMID42483856
PMCPMC13389827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.