Evidence map›Paper›PMID 42483786›Full record

ReviewInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age.

Agnaldo Lopes da Silva-Filho, Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea R Genazzani, Diana Ramos, Elizabete Argale, Enrique Herrera, Martha Hickey

Abstract readConsensus StatementReview
In one paragraph

Review in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agnaldo Lopes da Silva-FilhoDepartment of Gynecology and Obstetrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-8486-7861
Suvarna KhadilkarFIGO Committee on Women at Menopausal Age, FIGO, London, UK.
Hema DivakarFIGO Division of Well Woman HealthCare, FIGO, London, UK.
Chiara BenedettoFIGO Committee on Women at Menopausal Age, FIGO, London, UK.
Andrea R GenazzaniFIGO Committee on Women at Menopausal Age, FIGO, London, UK.
Diana RamosFIGO Committee on Women at Menopausal Age, FIGO, London, UK.
Elizabete ArgaleFIGO Committee on Women at Menopausal Age, FIGO, London, UK.
Enrique HerreraFIGO Committee on Women at Menopausal Age, FIGO, London, UK.
Martha HickeyFIGO Committee on Women at Menopausal Age, FIGO, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in cancer screening, diagnosis, and treatment have greatly improved survival rates among women with gynecologic cancers. More survivors now live long enough to experience treatment-related menopause. Vasomotor symptoms, genitourinary syndrome of menopause, sexual dysfunction, sleep issues, and long-term risks from estrogen deficiency can seriously impact quality of life. Despite increased survival, managing menopausal symptoms remains difficult, as concerns about cancer recurrence and hormone therapy safety often result in inconsistent or insufficient treatment. This article explores clinical considerations for menopausal hormone therapy (MHT) in women with a history of gynecologic cancer. It reviews evidence on the safety of MHT after vulvar, vaginal, cervical, uterine, and ovarian cancers, providing an overview of tumor histology, stage, and hormonal sensitivity. It also synthesizes observational studies, systematic reviews, and international guidelines to help clinicians deliver menopausal care to cancer survivors. Current evidence suggests that systemic MHT may be suitable for carefully chosen survivors of non-hormone-dependent gynecologic cancers, including most vulvar, vaginal, cervical, and epithelial ovarian cancers. Patients with hormonally sensitive tumors should generally avoid systemic MHT, while local vaginal hormonal administration and non-hormonal options remain important in these cases. Given the disproportionate burden of gynecologic cancers in low- and middle-income countries, where younger women face increased risks of treatment-induced menopause and limited survivorship resources, this paper emphasizes context-specific, resource-aware strategies to promote equitable care. By enhancing personalized and evidence-based decision-making, we aim to improve quality of life for women during menopause after cancer treatment, while ensuring safe, fair, and widely applicable survivorship approaches.

Indexed as

Cancer SurvivorsEstrogen Replacement TherapyGenital Neoplasms, FemaleHormone Replacement TherapyMenopausePostmenopauseFemaleHumansMiddle AgedQuality of Lifecancer survivorsfemale genital neoplasmsgenitourinary syndrome of menopausehormone replacement therapyhot flashespremature menopausequality of lifetreatment‐induced menopause

Identifiers

PMID42483786
PMCPMC13505246

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.