Evidence map›Paper›PMID 42483664›Full record

ReviewSmall science2026

Stimuli-Responsive Aggregation-Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications.

Zhaohua Xu, Deyue Kong, Xiaoru Li, Miao Zhu, Haili Yan, Chenyang Zhang, Xiaochun Wang, Duiping Feng, Jiangfeng Du

Abstract readReview
In one paragraph

Review in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhaohua XuDepartment of Medical Imaging Shanxi Key Laboratory of Intelligent Imaging First Hospital of Shanxi Medical University Taiyuan Shanxi Province China.
Deyue KongSchool of Traditional Chinese Medicine Shanxi University of Chinese Medicine Jinzhong Shanxi Province China.
Xiaoru LiCollege of Clinical Medicine Inner Mongolia Medical University Hohhot Inner Mongolia China.
Miao ZhuSchool of Pharmacy Shanxi Medical University Taiyuan Shanxi Province China.
Haili YanDepartment of Medical Imaging Shanxi Key Laboratory of Intelligent Imaging First Hospital of Shanxi Medical University Taiyuan Shanxi Province China.
Chenyang ZhangDepartment of Radiation Oncology Peking University Third Hospital Beijing China.
Xiaochun WangDepartment of Medical Imaging Shanxi Key Laboratory of Intelligent Imaging First Hospital of Shanxi Medical University Taiyuan Shanxi Province China.
Duiping FengDepartment of Oncological and Vascular Intervention First Hospital of Shanxi Medical University Taiyuan Shanxi Province China.ORCID https://orcid.org/0000-0003-4516-3797
Jiangfeng DuDepartment of Medical Imaging Shanxi Key Laboratory of Intelligent Imaging First Hospital of Shanxi Medical University Taiyuan Shanxi Province China.ORCID https://orcid.org/0000-0002-8533-5509

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smart-responsive aggregation-induced emission (AIE) materials have emerged as promising bio-nanomaterials for tumor diagnosis and therapy due to their enhanced fluorescence in aggregated states, overcoming the aggregation-caused quenching of traditional fluorophores. These materials enable the construction of efficient imaging and therapeutic platforms in complex biological environments. Stimuli-responsive AIE systems can be categorized into pH-, redox-, thermo-, enzyme-responsive, and externally triggered types. Despite significant progress in AIE-based tumor imaging and therapy, critical challenges in their rational design and biomedical application remain insufficiently addressed. This review summarizes recent advances in stimuli-responsive AIE materials for tumor theranostics, focusing on their design strategies, functional mechanisms, and representative applications. Current limitations and future perspectives are also discussed to guide the development of next-generation AIE-based platforms.

Indexed as

aggregation‐induced emission (AIE)bioimagingnanomedicinestimuli‐responsive materialstumor theranostics

Identifiers

PMID42483664
PMCPMC13387345

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.