ArticlePrzeglad gastroenterologiczny2026
Prognostic value of TRIM24 expression in gastric cancer and various human solid tumours: a comprehensive cross-sectional, and meta-analysis study.
Article in Przeglad gastroenterologiczny, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Tripartite motif-containing 24 (TRIM24) protein has been reported to be dysregulated in various cancers. Aim: This study assessed the TRIM24 expression pattern in patients with gastric cancer (GC). Additionally, a comprehensive meta-analysis was performed to clarify the importance of TRIM24 expression in predicting the outcomes of various malignancies. Material and methods: The expression levels of TRIM24 in 40 cancerous and adjacent normal tissues were determined by quantitative real-time PCR (qRT-PCR). Patients were further classified into two groups based on high and low TRIM24 levels. The relationship between TRIM24 expression, various clinical features, b-catenin, and overall survival (OS) was evaluated using appropriate statistical analyses. Additionally, a comprehensive meta-analysis was conducted to assess the prognostic value of TRIM24 levels in various malignancies. The pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the possible associations. Results: TRIM24 expression was higher in GC tissues compared with their corresponding normal tissues (fold change = 2.69, Conclusions: TRIM24 overexpression is strongly associated with tumour staging, metastasis, and unfavourable survival outcomes, highlighting its potential utility as both a useful prognostic marker and a potential therapeutic target across various malignancies.
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