ArticleJournal of asthma and allergy2026
Asthma with Preserved Ratio Impaired Spirometry: A Distinct Phenotype Associated with Increased Exacerbation Burden.
Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Asthma with Preserved Ratio Impaired Spirometry: A Distinct Phenotype Associated with Increased Exacerbation Burden.Journal of asthma and allergy · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Purpose: Asthma is a heterogeneous disease, and identifying phenotypes associated with an increased exacerbation burden is clinically important. Preserved ratio impaired spirometry (PRISm) has been linked to adverse health outcomes; however, its clinical impact on asthma remains incompletely defined. The aim of this study was to determine whether asthma with PRISm represents a distinct clinical phenotype characterised by an increased exacerbation burden. Patients and Methods: We retrospectively analysed data from 1,411 adult patients with asthma. The patients were categorised into three groups according to %FEV Results: Age, sex, smoking status, and body mas index (BMI) significantly differed among the groups. The PRISm group had a significantly higher frequency of severe acute exacerbations than the control group, whereas no significant difference was observed between the PRISm and airflow obstruction groups. Severe asthma was more frequent in the PRISm group than in the control group, but its frequency was comparable between the PRISm and airflow obstruction groups. In multinomial logistic regression analysis, relative to the control group, the PRISm group was characterised by higher BMI (1.08 (1.03-1.13), adjusted odds ratio (95% confidence interval)), longer asthma duration (1.02 (1.00-1.03)), and higher severe acute exacerbation (2.31 (1.46-3.64)). Relative to the airflow obstruction group, the PRISm group was characterised by higher BMI (1.15 (1.07-1.24)) and shorter asthma duration (0.97 (0.96-0.99)), while the frequency of severe acute exacerbations (1.39 (0.78-2.48)) did not differ significantly between them. Conclusion: Asthma with PRISm may represent a distinct and clinically relevant phenotype associated with a substantial exacerbation burden. Its clinical importance lies not merely in its spirometric profile, but in the identification of a subgroup of patients who may require closer surveillance and earlier optimisation of management.
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