Evidence map›Paper›PMID 42483504›Full record

ReviewFrontiers in plant science2026

Green synthesis revolution: harnessing biological factories for sustainable insect pheromone production in agriculture.

Ke-Xin Wang, Yi-Han Xia

Abstract readReview
In one paragraph

Review in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ke-Xin WangSchool of Agriculture and Biotechnology, Sun Yat-sen University, Shenzhen, China.
Yi-Han XiaSchool of Agriculture and Biotechnology, Sun Yat-sen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insect sex pheromones enable species-specific monitoring and mating disruption in integrated pest management, but wider adoption is limited by manufacturing complexity, particularly for molecules requiring stringent control of chain length, double-bond position/geometry, and terminal functional groups. Synthetic biology and lipid metabolic engineering have enabled microbial and plant "biological factories" to produce fatty-acid-derived moth pheromone components from renewable carbon. This review organizes pheromone biomanufacturing around structure-defining biochemical decision points and the corresponding enzyme modules, summarizes the current gene pool (desaturases, reductases, β-oxidation-linked chain shortening, and terminal conversions), and discusses key host constraints that govern product titer, product spectrum, and host fitness, including precursor supply, competing sinks, redox balance, compartmentalization, and product toxicity. We compare yeast and plant platforms and synthesize lessons from representative case studies, highlighting recurring engineering strategies and current limitations. Finally, we outline priorities for improving predictability and scalability, including expanding enzyme selectivity/coverage and implementing standardized benchmarking supported by modern genome engineering and data-driven design.

Indexed as

insect pheromoneintegrated pest managementlipid metabolic engineeringplant factoryyeast cell factory

Identifiers

PMID42483504
PMCPMC13385670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.