Evidence map›Paper›PMID 42483462›Full record

ArticleFrontiers in cardiovascular medicine2026

Discrimination of sustained VT in structural heart disease using LGE-CMR and computational simulation: moving beyond LVEF.

Kun Zuo, Kuibao Li, Lucheng Xu, Yiming Wang, Shiwei Lu, Zhaokai Kong, Zhenyin Fu, Jianjun Zhang, Ruiqing Dong, Ling Xia and 2 more

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Kun Zuo *Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Kuibao Li *Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Lucheng XuSchool of Biomedical Engineering, Dalian University of Technology, Dalian, China.
Yiming WangSchool of Biomedical Engineering, Dalian University of Technology, Dalian, China.
Shiwei LuSchool of Biomedical Engineering, Dalian University of Technology, Dalian, China.
Zhaokai KongCollege of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Zhenyin FuCollege of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Jianjun ZhangHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Ruiqing DongDepartment of Cardiology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China.
Ling XiaCollege of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Dongdong DengSchool of Biomedical Engineering, Dalian University of Technology, Dalian, China.
Zheng LiuHeart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sustained ventricular tachycardia (VT) is a major cause of sudden cardiac death in structural heart disease (SHD). Risk stratification based on left ventricular ejection fraction (LVEF) remains suboptimal. This study aimed to develop an exploratory model integrating late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) scar characteristics with computational VT simulation to discriminate sustained VT, compared against LVEF. Methods: In this single-centre retrospective study, consecutive patients with suspected SHD who underwent LGE-CMR were enrolled. Patients with LGE-positive underwent quantitative scar analysis, personalized digital heart-twin reconstruction, and virtual electrophysiological simulation. Results: Among 82 patients (mean age 59.1 years; 82.9% male), 15 experienced sustained VT. Lower LVEF was associated with sustained VT ( Conclusion: The LGE-VTsim index, integrating quantitative LGE-CMR scar assessment with computational simulation, represents a promising exploratory parameter in identifying patients at risk of sustained VT in SHD, beyond LVEF.

Indexed as

cardiac magnetic resonancecomputational simulationrisk stratificationstructural heart diseaseventricular tachycardia

Identifiers

PMID42483462
PMCPMC13385657

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