Evidence map›Paper›PMID 42483453›Full record

ArticleFrontiers in cardiovascular medicine2026

Greater weekly exercise volume is associated with lower prevalence of metabolic comorbidities, psychiatric conditions, and exertional symptoms in youth athletes undergoing pre-participation screening: an observational study.

Grace Qiu, Seong Kyu Kim, Douglas Corsi, Alexander G Hajduczok, Imran Masood, Daniel Underberg, Brian Osler, Drew Johnson, David Shipon

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Grace QiuDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Seong Kyu KimSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.
Douglas CorsiRutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, United States.
Alexander G HajduczokOklahoma Heart Institute, Tulsa, OK, United States.
Imran MasoodKeck School of Medicine, Children's Hospital of Los Angeles, Heart Institute, University of Southern California, Los Angeles, CA, United States.
Daniel UnderbergDivision of Cardiology, Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, United States.
Brian OslerDivision of Cardiology, Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, United States.
Drew JohnsonDivision of Cardiology, Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, United States.
David ShiponDivision of Cardiology, Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Physical activity has been associated with improved cardiovascular health outcomes in adults. However, the specific associations between physical activity volume and cardiovascular outcomes in youth athletes are less defined. Methods: This study analyzed data from the HeartBytes National Youth Database, compiled from Simon's Heart. Simon's Heart is a nonprofit organization that includes information from sports pre-participation examinations for adolescents. The dataset encompasses demographics, electrocardiogram (ECG) findings, and exercise-related symptoms. Youth athletes' self-reported weekly physical activity volume was classified into four levels: <2 h, 2-5 h, 5-10 h, and >10 h, with less than 2 h taken as the reference group. Given the physical diMerences among athletes aged 12 to 20, the sample was stratified into middle and high school athlete groups. Logistic regression analysis was performed to evaluate the association between weekly exercise volume and cardiovascular risk factors, controlling for the confounding eMects of age, race, sex, body mass index, and area-level socioeconomic status. Results: Among 7,048 youth athletes (median age 15.1 years; interquartile range: 13.6-16.5), most were male (60.7%) and White (85.5%). Increased weekly exercise volume was associated with lower odds of attention deficit hyperactivity disorder (ADHD), anxiety or depression, and obesity in both middle and high school athletes. Greater exercise volume high school athletes, though these did not reach statistical significance. Greater weekly physical activity volume was associated with lower prevalence of cardiovascular disease risk factors, psychiatric comorbidities, and exertional symptoms in youth athletes. Given the cross-sectional design, causal relationships cannot be established and further studies are needed to clarify the clinical significance of these findings.

Indexed as

exercise volumeexertional symptomspre-participation screeningpsychiatric comorbiditiesyouth athletes

Identifiers

PMID42483453
PMCPMC13385190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.