Evidence map›Paper›PMID 42483435›Full record

ArticleJournal of human immunity2026

A case of progressive multifocal leukoencephalopathy in an adult patient with ADA-SCID.

Hannah Shin, Lori Broderick, Jessica Azevedo, Caitlin Mulligan, Kari Hird, Vanessa Goodwill, Courtney Parkin, Stephanie Mortensen, Madisen Traveller, Ahmad Rayes and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hannah ShinDivision of Allergy & Immunology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0009-3572-9073
Lori BroderickDivision of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of California, San Diego Rady Children's Hospital, San Diego, CA, USA.ORCID https://orcid.org/0000-0001-6147-7097
Jessica AzevedoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0006-6363-2664
Caitlin MulliganDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-7164-6090
Kari HirdDivision of Neuropathology, Department of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0009-0005-8003-9144
Vanessa GoodwillDivision of Neuropathology, Department of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0001-7665-7146
Courtney ParkinDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0009-0004-9599-7575
Stephanie MortensenDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0009-0008-4895-0140
Madisen TravellerDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0009-0004-4115-0635
Ahmad RayesDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0002-6352-9740
John BohnsackDivision of Pediatric Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-1392-9727
Donald B KohnDepartments of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-1840-6087
Teresa K TarrantDivision of Rheumatology and Immunology, Department of Medicine, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0003-4067-5363
Michael HershfieldDivision of Rheumatology and Immunology, Department of Medicine, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0003-3589-8554
Jonathan J LyonsDivision of Allergy & Immunology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-2346-8189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report describes progressive multifocal leukoencephalopathy in a patient with ADA-SCID status after gene therapy. Persistent metabolic dysfunction likely contributed to JC virus reactivation, highlighting this rare complication of ADA-SCID and incomplete reconstitution seen with early protocols.

Identifiers

PMID42483435
PMCPMC13387100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.