Evidence map›Paper›PMID 42483299›Full record

ArticleEuropean heart journal. Digital health2026

Extended reality simulator for dynamic visualization and evaluation of stereotactic arrhythmia radioablation (STAR) treatment plans within RAVENTA trial.

Domenico Riggio, Joana Leitão, Melanie Grehn, Judit Boda-Heggemann, Adrian Zaman, João Seco, Oliver Blanck, Maria Francesca Spadea

Abstract read
In one paragraph

Article in European heart journal. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Domenico RiggioInstitute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131 Karlsruhe, Germany.ORCID https://orcid.org/0009-0006-4967-880X
Joana LeitãoDivision of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Melanie GrehnDepartment of Radiation Oncology, University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3/Haus L, 24105 Kiel, Schleswig-Holstein, Germany.
Judit Boda-HeggemannDepartment of Radiation Oncology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Adrian ZamanDepartment of Internal Medicine III, Cardiology, University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3/Haus K3, 24105 Kiel, Schleswig-Holstein, Germany.
João SecoDivision of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Oliver BlanckDepartment of Radiation Oncology, University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3/Haus L, 24105 Kiel, Schleswig-Holstein, Germany.
Maria Francesca SpadeaInstitute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131 Karlsruhe, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic arrhythmia radioablation (STAR) represents an emerging non-invasive treatment for therapy-refractory ventricular tachycardia. Yet, planning remains challenged by multimodal cardiac imaging integration, electroanatomical mapping (EAM) transfer, and cardiorespiratory motion effects on dose delivery. Current radiotherapy (RT) planning systems offer mainly static visualization and limited access to intramural myocardial structures, hindering communication between cardiology and radiation oncology teams. We present a novel extended reality (XR) simulator designed to dynamically visualize STAR-relevant imaging and planning data. The system integrates diastolic cardiac CT, respiratory-binned 4DCT, anatomical segmentations, EAM data, and phase-recomputed RT dose distributions within an XR environment. Cardiac structures are propagated across respiratory phases using deformable registration, while dose distributions are recomputed on each respiratory-binned CT, enabling phase-specific inspection of dose conformality for both planning target volumes (PTVs) and cardiac target volumes (CardTVs). The resulting time-resolved volumetric dataset is rendered in XR, allowing clinicians to explore cardiac motion, visualize intramural dose deposition, and jointly assess target and organ-at-risk dynamics. This supports qualitative evaluation of dose-motion interplay and interdisciplinary interpretation of intramural targets. The system was tested on three STAR patients enrolled in the RAVENTA trial. Motion analysis revealed PTV centroid displacement amplitudes over the breathing cycle of up to 17.5, 10.2, and 8.9 mm for patients 1, 2, and 3, respectively, with conformity number variations of 0.38, 0.34, and 0.19. Expert evaluation showed positive perceived utility for target-anatomy-dose understanding, motion interpretation, and multidisciplinary communication. This proof-of-concept demonstrates the feasibility and potential clinical value of XR-based motion-aware dose visualization for STAR planning.

Indexed as

Extended realityMixed realityMultidisciplinary therapy planningMultimodal data integrationStereotactic arrhythmia radioablationVentricular tachycardia

Identifiers

PMID42483299
PMCPMC13387070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.