Evidence map›Paper›PMID 42483285›Full record

ArticleMaternal-fetal medicine (Wolters Kluwer Health, Inc.)2026

Global, Regional, and National Burden of Infertility Attributable to Sexually Transmitted Infections From 1990 to 2021, With Projections to 2050.

Ning Zhang, Run Miao, Haoyu He, Yuzhou Gao, Zhikang Zhang, Dongmei Ji

Abstract read
In one paragraph

Article in Maternal-fetal medicine (Wolters Kluwer Health, Inc.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ning ZhangDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Run MiaoDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Haoyu HeDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Yuzhou GaoDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Zhikang ZhangDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Dongmei JiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the specific impact of sexually transmitted infections (STIs) on infertility including differences in disease burden among different regions and populations and temporal trends. Methods: Data on STI-attributable infertility were extracted from the Global Burden of Diseases Study 2021. The study focused on two types of infertility (primary and secondary) and three STIs (chlamydia, gonococcal, and other STIs). The disease burden was measured using the age-standardized prevalence rate (ASPR) and the age-standardized years lived with disability (YLD) rate (ASYR). The estimated annual percent change (EAPC) was calculated to determine temporal variations. Temporal trends were modeled using joinpoint analysis and the age-period-cohort-Web tool. Finally, future trends were predicted using the Bayesian age-period-cohort model. Results: In 2021, there were 18,413,845 (95% uncertainty interval ( Conclusion: Infertility attributable to STIs remains a critical public health challenge, with a projected increasing trend through 2050. Global efforts to reduce the burden of infertility should focus on improving STI prevention, diagnosis, and treatment strategies, especially in regions with low and middle SDI levels.

Indexed as

Global burden of diseaseIndividuals of reproductive ageInfertilitySexually transmitted infections

Identifiers

PMID42483285
PMCPMC13387761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.