ArticleFrontiers in cell and developmental biology2026
Prognostic value of C-reactive protein-albumin-lymphocyte index (CALLY) in patients with endometrial cancer under radical surgery.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The C-reactive protein-albumin-lymphocyte (CALLY) index has been reported to possess prognostic utility in several malignancies. However, its relevance in endometrial cancer (EC) has not been fully elucidated. This investigation was designed to evaluate the prognostic predictive value of the preoperative CALLY index in individuals with EC undergoing radical surgery. Methods: A retrospective analysis included 288 patients from the First Affiliated Hospital of Soochow University as the training cohort, with 153 patients from Changzhou People's Hospital serving as the validation cohort. The cutoff value and prognostic significance of the CALLY index were established using statistical analyses, and a nomogram was subsequently developed. Results: A decreased CALLY index was identified as an independent risk factor for overall survival among EC patients. The time-dependent AUC of the CALLY index for 1-year, 3-year and 5-year survival was numerically greater than that of conventional inflammatory markers, though the difference was not statistically significant. The nomogram integrating CALLY, age, International Federation of Gynecology and Obstetrics (FIGO) stage, and pathological subtype demonstrated strong predictive capability in both the training cohort and validation cohort, outperforming FIGO staging alone. Conclusion: The CALLY index is readily available, cost-effective, and may serve as a promising biomarker for preoperative prognostic evaluation in EC. The developed nomogram may facilitate individualized therapeutic planning and offer practical guidance for the precision diagnosis and treatment of EC.
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