ArticleFrontiers in immunology2026
IL-33 induces stronger responses in female mast cells and neutrophils: a role for the JNK pathway.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Allergic diseases exhibit considerable sex-based variations, with greater incidence of allergic asthma, atopic dermatitis, food allergy, and chronic urticaria among adult females. This female dominance may be explained by differences in inflammatory signaling. Methods: We used primary mouse mast cells, neutrophils, and eosinophils as well as two mouse models of IL-33-induced inflammation to measure male and female responses to IL-33. Results: We show that the allergy-associated cytokine IL-33 elicits stronger responses from female mast cells and neutrophils compared to males, both Discussion: These data show that IL-33 induces female-dominant mast cell and neutrophil responses, partly via female-selective JNK signaling.
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