ArticleChemical science2026
Chiral 3-acyl-2-pyrrolines as strategic hubs toward polycyclic pyrrolidines
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
We present a synthetic strategy for the construction of chiral polycyclic pyrrolidines through enantioenriched 3-acyl-2-pyrrolines as multifunctional synthetic hub molecules. These intermediates were produced by a silver-catalyzed enantioselective Michael addition-cyclization between α-substituted isocyanoacetates and nonactivated β-substituted alkyl enones, enabled by a chiral prolinol-phosphine-
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