SynthesisFrontiers in public health2026
Age differences in psychological comorbidity in atopic dermatitis: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: While the association between atopic dermatitis (AD) and psychological comorbidities is established, whether this risk differs across developmental stages remains unclear. This study aimed to quantify and compare this risk and examine key methodological sources of heterogeneity. Methods: We conducted a systematic search of PubMed, Embase, and Cochrane Library for studies published up to October 2025. Pooled effect estimates [hazard ratios (HRs) from cohort/case-control studies and odds ratios (ORs) from cross-sectional studies] were calculated using random-effects models. Ninety-five percent prediction intervals were calculated for all meta-analyses. The study protocol was registered with PROSPERO (CRD420251244849). Results: We included 28 studies of various observational designs (cohort, cross-sectional, and case-control) in the meta-analysis. The analysis revealed numerically higher risk estimates for depression, anxiety, and suicidality among pediatric and adolescent AD patients compared with adults. Specifically, for depression, the pooled HR from cohort studies in youth was 2.16 (95% CI: 1.56-2.98; Conclusion: The psychological burden of AD appears most pronounced in children and adolescents, but the very high heterogeneity across studies limits the certainty of this finding. Therefore, the results should be interpreted cautiously. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=1244849, identifier: CRD420251244849.
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