Evidence map›Paper›PMID 42483059›Full record

ArticleFrontiers in public health2026

Occurrence of halonaphthoquinone disinfection byproducts in Shanghai's drinking water and the hepatotoxic effects on lipid accumulation.

Zhenzhen Tian, Yongqing Diao, Jielan Hu, Yuxin Li, Xi Yu, Xia Wang

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Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Zhenzhen Tian *Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Yongqing Diao *Shanghai Qingpu District Center for Disease Control and Prevention, Shanghai, China.
Jielan HuShanghai Qingpu District Center for Disease Control and Prevention, Shanghai, China.
Yuxin LiShanghai Qingpu District Center for Disease Control and Prevention, Shanghai, China.
Xi YuShanghai Qingpu District Center for Disease Control and Prevention, Shanghai, China.
Xia WangKey Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In recent years, aromatic disinfection by-products (DBPs) have attracted widespread concern due to their elevated concentration and significant toxicity. Recent studies have identified a new class of DBPs, halonaphthoquinones (HNQs), during drinking water disinfection processes, which exhibit both high occurrence levels and considerable toxicological risks. Methods: This study established a liquid-liquid extraction coupled with HPLC-MS/MS method to determine HNQs levels in drinking water. In July 2024, source and finished water samples were collected from three drinking water treatment plants (Plants A, B, and C) in Shanghai, which source their water from the Q and J reservoirs. A total of 9 source and 9 finished water samples were collected in each plant. Based on the HNQs concentrations detected in finished water, the effects of mixed HNQs exposure on lipid accumulation in HepG2 human hepatoma cell line in vitro were investigated. Results: In finished water, MCNQ showed the highest levels, averaging 8.7-13.05 ng/L and peaking at Plant A (13.05 ng/L, Discussion: These results suggest that HNQs may be important risk factors for metabolic dysfunction-associated fatty liver disease (MAFLD), and further observation and validation of the impact of HNQs on MAFLD are needed in the future.

Indexed as

DisinfectantsDrinking WaterLipid MetabolismNaphthoquinonesWater Pollutants, ChemicalChinaChromatography, High Pressure LiquidDisinfectionHep G2 CellsHumansTandem Mass SpectrometryWater PurificationDisinfectantsDrinking WaterNaphthoquinonesWater Pollutants, Chemicaldisinfection by-productshalonaphthoquinoneshigh performance liquid chromatography–tandem mass spectrometrylipid accumulationoxidative stress

Identifiers

PMID42483059
PMCPMC13385284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.