Evidence map›Paper›PMID 42483054›Full record

ArticleFrontiers in public health2026

Micronutrients in relation to cardiometabolic risk factors among middle-aged and older Chinese adults: protocol for an exploratory longitudinal panel study with multi-omics profiling.

Zhiyue Xu, Xueying Zhao, Lugao Tian, Xinghuang Liu, Min Xiang, Pengcheng Yang, Rongchuan Huang, Xiaotian Xie, Dongke Wang, Ziqian Zhang and 9 more

Abstract read
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In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Zhiyue Xu *Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xueying Zhao *Division of Gastroenterology, Central Hospital of Hefeng County, Enshi, Hubei, China.
Lugao Tian *Department of Gastroenterology, Yichang Central People's Hospital, Yichang, Hubei, China.
Xinghuang LiuDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Min XiangKey Laboratory of Environment and Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Pengcheng YangDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Rongchuan HuangKey Laboratory of Environment and Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiaotian XieDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Dongke WangDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ziqian ZhangKey Laboratory of Environment and Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jing HeDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Chujie TuDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Enli ZhangDivision of Gastroenterology, Central Hospital of Hefeng County, Enshi, Hubei, China.
Guoxing ZhuDivision of Gastroenterology, Central Hospital of Hefeng County, Enshi, Hubei, China.
Chao GuDivision of Gastroenterology, Central Hospital of Hefeng County, Enshi, Hubei, China.
Hong YangDivision of Gastroenterology, Central Hospital of Hefeng County, Enshi, Hubei, China.
Xiaohua HouDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Liangle YangKey Laboratory of Environment and Health, Ministry of Education, and State Key Laboratory of Environmental Health (Incubating), Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Tao BaiDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The escalating prevalence of cardiometabolic risk factors (CRFs) contributes to increased risks of cardiometabolic diseases. Micronutrients, essential for nearly all physiological functions, have been widely linked to CRFs. However, the joint associations of micronutrient mixtures with CRFs, as well as the potential biological pathways remain incompletely understood. To address this gap, this protocol describes the rationale and design of a longitudinal panel study, which included 205 adults with four repeated seasonal visits in Hefeng County, Enshi Prefecture, Hubei province, China. This project aimed to (1) evaluate the individual and joint associations of biomarker-based micronutrient profiles with CRFs; (2) characterize biological samples using multi-omics approaches to explore candidate biomarkers and potential pathways linking micronutrient profiles with cardiometabolic risk. The planned analyses are expected to help identify relationship of micronutrient profiles with altered biological effects and cardiometabolic diseases risk, and provide a framework for future validation studies and precision nutrition research.

Indexed as

Cardiometabolic Risk FactorsCardiovascular DiseasesMicronutrientsAgedBiomarkersChinaEast Asian PeopleFemaleHumansLongitudinal StudiesMaleMiddle AgedMultiomicsRisk FactorsBiomarkersMicronutrientsaging populationbiomarkerscardiometabolic risk factorsmicronutrientsmulti-omicspanel study

Identifiers

PMID42483054
PMCPMC13385261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.