ArticleFrontiers in aging neuroscience2026
Integrated PET/MRI for the evaluation of gray matter atrophy and metabolic changes in idiopathic Parkinson's disease.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The underlying mechanisms linking structural and metabolic alterations of idiopathic Parkinson's disease (IPD) remain poorly understood. Utilizing integrated PET/MR for its precise spatial correlation, this study investigated the temporal relationship between gray matter (GM) atrophy and reduced FDG SUVR (RFS) across IPD stages to provide insights for early diagnosis. Methods: This prospective study recruited 90 IPD patients stratified by Hoehn-Yahr (H-Y) stage into mild, moderate, and severe groups, alongside 30 age-matched healthy controls (HC). All participants underwent integrated Result: With disease progression, GM atrophy and RFS in IPD patients gradually extend from focal to widespread patterns. A characteristic pattern of cerebral hypermetabolism was observed in IPD. H-Y stage demonstrated a significant inverse correlation with the extent of both brain GM atrophy (affecting 82 out of 90 regions) and RFS (affecting 20 regions). Conversely, it was positively correlated with hypermetabolism in regions including the sensorimotor cortex, amygdala, and globus pallidus. Moderate correlations between atrophy and RFS were confined to the left inferior parietal lobule ( Conclusion: Widespread RFS predominates during early stages, whereas structural atrophy gradually becomes the dominant imaging feature as the disease advances. These alterations are significantly correlated with disease severity, underscoring the potential of multimodal imaging biomarkers for the early diagnosis of IPD and monitor its progression.
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