Evidence map›Paper›PMID 42483035›Full record

ArticleOpen forum infectious diseases2026

The Case for N-acetylcysteine in Dengue Associated Liver Injury: Time for Definitive Evidence.

Angela McBride, Nguyen Lam Vuong, Sudeep Adhikari, Su Myat Han, Po Ying Chia, Huynh Trung Trieu, Phung Khanh Lam, Ho Quang Chanh, Giri Rajahram, Peter Horby and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Angela McBridePandemic Sciences Institute, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-5507-0415
Nguyen Lam VuongOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0003-2684-3041
Sudeep AdhikariOxford University Clinical Research Unit Nepal, Lalitpur, Nepal.ORCID https://orcid.org/0000-0003-2659-3425
Su Myat HanSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.ORCID https://orcid.org/0000-0003-1052-2219
Po Ying ChiaNational Centre for Infectious Diseases, Singapore, Singapore.ORCID https://orcid.org/0000-0002-8797-9527
Huynh Trung TrieuHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0003-4922-6548
Phung Khanh LamSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0001-7968-473X
Ho Quang ChanhOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0002-1840-0868
Giri RajahramDepartment of Medicine, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia.ORCID https://orcid.org/0000-0002-8123-476X
Peter HorbyPandemic Sciences Institute, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-9822-1586
Tsin Wen YeoNational Centre for Infectious Diseases, Singapore, Singapore.ORCID https://orcid.org/0000-0002-4060-7902
Evelyne KestelynPandemic Sciences Institute, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-5728-0918
James WatsonPandemic Sciences Institute, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-5524-0325
Truong Ngoc TrungHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Sophie YacoubPandemic Sciences Institute, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-2910-7819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue-associated liver injury is common, prognostically significant, and associated with high mortality at severe thresholds. Oxidative stress is a key, potentially modifiable mechanism. N-acetylcysteine has strong biological plausibility and supportive preclinical data, but clinical evidence remains limited, underscoring the need for well-designed randomized trials to inform practice and policy.

Indexed as

acute liver failuredenguehost-directed therapyliver injuryN-acetylcysteine

Identifiers

PMID42483035
PMCPMC13386172

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.