ArticleFrontiers in cellular and infection microbiology2026
Clinical characteristics, co-detection patterns and prognostic risk factors of human metapneumovirus infection in children: a retrospective study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical characteristics and outcomes of respiratory syncytial virus and human metapneumovirus ınfections in children under five years of age.European journal of pediatrics · 2026Article
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7 authors.
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Abstract
Objective: To investigate clinical characteristics, co-detection patterns, and prognostic risk factors of human metapneumovirus (hMPV) infection in children. Methods: Retrospective study of 621 children with laboratory-detected hMPV infection. Clinical data, laboratory indicators, and co-detection status were analyzed. Multivariate logistic regression identified independent risk factors for severe pneumonia. Results: Median age was 3.50 years (IQR 1.75-4.75). Of 621 patients, 399 (64.3%) had Single-detection and 222 (35.7%) co-detection, with viral-viral co-detection dominant (68.9%) and rhinovirus the most common co-pathogen (39.6%). Only platelet count and aspartate aminotransferase differed significantly between groups (both P<0.01), with all inflammatory markers improving post-treatment (all P<0.001). Viral-bacterial co-detection was associated with longer hospitalization (median 6.5 days) and higher severe pneumonia rate (14.5%, both P<0.01). Multivariate analysis identified Conclusion: hMPV infection is most prevalent in preschool children. Viral-bacterial co-detection was associated with worse clinical outcomes.
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