Evidence map›Paper›PMID 42482938›Full record

ArticleFrontiers in microbiology2026

Relationships of oxidative stress, inflammation and gut microbiota with cognitive impairment in first-episode major depressive disorders: a pilot study in China.

Hehua Li, Baoyuan Zhu, Yuanyuan Huang, Shuhao Chen, Ziyun Zhang, Jingping Wu, Fengchun Wu, Kai Wu, Yuping Ning

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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hehua Li *The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Baoyuan Zhu *School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Yuanyuan HuangThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Shuhao ChenSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.
Ziyun ZhangThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Jingping WuThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Fengchun WuThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Kai WuSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.
Yuping NingThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Cognitive impairment runs through the entire course of major depressive disorder (MDD). However, the relationships between cognitive impairment and the gut microbiota (GM) and their predicted metabolic pathways as well as peripheral blood indicators remains unclear. We aimed to explore these relationships. Method: Patients ( Results: In comparison with HCs, patients with MDD exhibited significant cognitive impairment, elevated SOD levels, enrichment of specific GM, and upregulation of microbial predicted metabolic pathways involving L-alanine, pyruvate, and salicortin. In patients with MDD, the salicortin biosynthesis pathway and pathways related to L-alanine metabolism were negatively correlated with the levels of Hcy and CRP, respectively, while the superpathway of Conclusion: Our research showed that the GM and their predicted metabolic pathways in patients with MDD were closely related to cognitive function and peripheral blood indicators, and that differences in these factors may manifest as oxidative stress and inflammation.

Indexed as

cognitive functiongut microbiotamajor depressive disordermetabolic pathwayperipheral blood indicators

Identifiers

PMID42482938
PMCPMC13385523

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