ArticleFrontiers in medicine2026
The impact of early nutritional and immune status assessment on all-cause mortality in patients with intracerebral hemorrhage in the intensive care unit: a retrospective study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Recent research has indicated that nutritional and immune status impact neurological outcomes. We assessed the association between the hemoglobin-albumin-lymphocyte platelet (HALP) score and all-cause mortality among patients with intracerebral hemorrhage (ICH). Methods: We retrospectively collected data from patients with ICH in two cohorts. Kaplan-Meier survival curves and restricted cubic spline (RCS) regression analysis were used to analyze the association between the HALP score and both short- and long-term outcomes. We also developed a risk prediction nomogram and validated it in an external cohort. Results: An analysis of 925 ICH patients from the MIMIC database revealed 30-day, 90-day, and 365-day mortality rates of 29.08%, 34.49%, and 41.84%, respectively. The Q1 group (HALP < 16.87) exhibited significantly higher short- and long-term mortality than the other groups (all Conclusion: Our findings indicate that a lower HALP score is associated with increased mortality in ICH patients. Additionally, we created a straightforward risk stratification tool based on this score to assist clinicians in identifying high-risk individuals.
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