EASIX as a moderately effective prognostic marker for mortality in severe acute pancreatitis: a retrospective study.

Lvyuan Shi, Lili Cao, Dingyuan Wan, Lietao Wang, Ping Li, Siyuan Chen, Zhongwei Zhang, Min He

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Lvyuan Shi *Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Lili Cao *Institute of Basic Medical College, Chengdu University, Chengdu, China.

Dingyuan WanDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Lietao WangDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Ping LiDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Siyuan ChenDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Zhongwei ZhangDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Min HeDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The endothelial activation and stress index (EASIX) has been proposed as a surrogate laboratory index reflecting endothelial activation and stress. This study aimed to evaluate the prognostic value of EASIX in patients with severe acute pancreatitis (SAP). Methods: This retrospective observational study analyzed 340 SAP patients hospitalized between December 2015 and December 2023. EASIX was calculated as LDH (U/L) × creatinine (mg/dL) / platelet count (10 Results: The overall mortality rate was 28.82%. Non-survivors exhibited significantly elevated EASIX levels compared to survivors ( Conclusion: EASIX is a moderately effective prognostic marker in SAP, with performance comparable to APACHE II. The developed predictive model incorporating EASIX shows improved accuracy over EASIX alone for mortality risk stratification, but external validation is needed before clinical application.

Indexed as

EASIXICUmortalitysevere acute pancreatitisshort-term prognosis

Identifiers

PMID42482914

DOI10.3389/fmed.2026.1854703

PMCPMC13386221

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