Evidence map›Paper›PMID 42482838›Full record

Observational studyInternational journal of chronic obstructive pulmonary disease2026

Carbon Emissions and Treatment Efficiency in Chronic Obstructive Pulmonary Disease: The Impact of Inhaled Bronchodilators and Corticosteroids.

Lun-Yu Jao, Mei-Chen Yang, Chung Lee, Yao-Kuang Wu, Kuo-Liang Huang, Wen-Lin Su, Chun-Yao Huang, I-Shiang Tzeng, Chou-Chin Lan

Abstract readObservational StudyComparative Study
In one paragraph

Observational study in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lun-Yu JaoDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Mei-Chen YangDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0000-0002-6503-5189
Chung LeeDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0009-0007-6062-6178
Yao-Kuang WuDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0000-0001-7898-6963
Kuo-Liang HuangDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Wen-Lin SuDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0000-0002-9065-2058
Chun-Yao HuangDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
I-Shiang TzengDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0000-0002-9047-8141
Chou-Chin LanDivision of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0000-0001-9376-6539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inhaled therapies are essential for chronic obstructive pulmonary disease (COPD) management but also contribute to healthcare-related carbon emissions. Real-world evidence linking inhaler-related carbon burden to clinical outcomes remains limited. This study evaluated the relationship between inhaler-related CO Methods: This retrospective single-center observational study included patients with COPD. Patients were categorized into four groups based on the inhaled therapy: long-acting muscarinic antagonists (LAMA) monotherapy, LAMA/long-acting β2-agonists (LABA), LABA/inhaled corticosteroids (ICS), and triple therapy (LAMA/LABA/ICS). Clinical outcomes, including pulmonary function test (PFT) parameters and health-related quality of life (HRQL), were assessed over one year. Total inhaler-related CO Results: Clinical improvements in HRQL and PFT were comparable across groups, with no significant differences in ΔFEV1, ΔFVC, or ΔCAT. However, CO Conclusion: High-intensity regimens were associated with substantially increased inhaler-related CO

Indexed as

Adrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsCarbon DioxideLungMuscarinic AntagonistsPulmonary Disease, Chronic ObstructiveAdministration, InhalationAgedDrug Therapy, CombinationFemaleHumansMaleMiddle AgedNebulizers and VaporizersQuality of LifeAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsCarbon DioxideMuscarinic Antagonistscarbon emissionschronic obstructive pulmonary diseasehealth-related quality of lifeinhalerpulmonary functiontreatment efficiency

Identifiers

PMID42482838
PMCPMC13387197

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.