ReviewFrontiers in oncology2026
Datopotamab deruxtecan in solid tumors: Recent research progress and clinical applications.
Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Following the approval of the first antibody-drug conjugate (ADC) for solid tumors, the therapeutic landscape in cancer has been revolutionized. Datopotamab deruxtecan (Dato-DXd) is a TROP2-targeting ADC which is composed of a humanized monoclonal antibody and a potent topoisomerase I inhibitor via a tetrapeptide-based cleavable linker. Based on data from multiple clinical trials, Dato-DXd has demonstrated compelling efficacy and a manageable safety profile. Herein, we provide an overview of recent published clinical trial data on Dato-DXd across various solid tumors. In addition, we propose future research directions to address critical issues in the clinical application of Dato-DXd, including optimal sequencing strategies with other TROP2-targeting ADCs, approaches to overcome drug resistance, and management of treatment-related adverse events.
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