SynthesisFrontiers in oral health2026
Hyperspectral imaging in oral oncology: a scoping review.
Synthesis in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oral cancer accounts for 177,000 deaths annually. Despite advances in surgical techniques and adjuvant therapies, the five-year survival rate for oral malignancies has shown limited improvement. Hyperspectral imaging (HSI) is a new non-invasive optical modality that extends medical imaging beyond the visible spectrum. This scoping review aims to map the extent, nature, and methodological characteristics of the existing literature on the application of HSI for the detection and characterization of oral cancer. It explores the clinical applications of HSI in oral oncology, outlines the technical and analytical approaches used, and evaluates its diagnostic performance and translational readiness in clinical practice. Methods: This scoping review used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines and followed the Population-Concept-Context(PCC) framework. A comprehensive search strategy was formulated to search across PubMed, ScienceDirect, Nature, LILACS, and Cochrane Library, and citation searching. Search was conducted by two independent reviewers using predefined inclusion and exclusion criteria. Microsoft Excel was used for data extraction. Descriptive synthesis was used to map the extent and nature of existing evidence, and narrative synthesis was used to identify patterns and methodological characteristics. Results: Out of 1,513 records identified, 15 studies were included. Most studies were published after 2017 and conducted in high-income countries. 13 studies were conducted Conclusion: HSI is a new emerging technology with applications in oral oncology. It provides a non-contact, objective and rapid alternative for margin assessment. With improved standardization, robust analytical models and clinical validation, it has the potential to be integrated into routine oral cancer management. Systematic Review Registration: https://doi.org/10.17605/OSF.IO/JQEGU.
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