ArticleYonsei medical journal2026
Coronary Artery Disease Prediction in Korean Patients with Familial Hypercholesterolemia: Analysis Involving Cholesterol Efflux Capacity.
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposePatients with familial hypercholesterolemia (FH) are at high risk of coronary artery disease (CAD), and its prediction is of great clinical importance. This study aimed to identify predictors of CAD and construct an effective risk prediction model for Korean patients with FH. MATERIALS AND
methodsClinical and laboratory data of 245 patients were collected from the Korean FH registry. CAD was defined as ≥50% coronary stenosis on invasive or computed tomographic angiography. The cholesterol efflux capacity (CEC) was measured using J774A1 cells and radiolabeled cholesterol. Predictors of CAD were identified by multivariable logistic regression analysis, and the best-performing prediction model was determined based on its statistical indices.
resultsThe participants' mean age was 49.1 years; 92 (37.6%) were male, and 41 (16.7%) had CAD. Age [odds ratio (OR) 1.05;
conclusionTraditional risk factors, including hypertension and HDL-C, were predictors of CAD in Korean patients with FH, whereas CEC was not. The resulting CAD prediction model demonstrated satisfactory performance in this population.
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