ArticleMedical physics2026
Accurate automated 3D lumbar spine reconstruction from biplanar X-rays using multi-task deep learning and anatomy-aware optimization.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccurate 3D assessment of the weight-bearing lumbar spine is crucial for diagnosing various spinal pathologies. However, existing biplanar X-ray reconstruction methods struggle with complex pathologies and low-contrast structures. PURPOSE: This study aims to propose a fully automated framework for high-accuracy 3D lumbar spine reconstruction from biplanar X-ray images.
methodsStatistical shape models (SSMs) of L1-L5 vertebrae were constructed from 270 lumbar CT scans. A multi-task deep learning network was designed to simultaneously isolate vertebral signals from biplanar X-rays and detect anatomical landmarks. Landmark predictions were used for pose initialization, followed by SSM-based 2D-3D registration using an anatomy-aware weighted optimization strategy that emphasized the transverse and spinous processes. The method was validated against patient-specific CT segmentations registered to the biplanar imaging geometry. The method was evaluated in subjects without significant osseous abnormalities and in pathological patients from an independent center.
resultsThe proposed network achieved Dice coefficients of 0.991 and 0.989 for anteroposterior and lateral vertebral signal isolation, respectively. The overall 3D reconstruction accuracy was 0.85 ± 0.24 mm. Reconstruction accuracy was 0.80 ± 0.15 mm in Center 1 and 1.32 ± 0.46 mm in the pathological cohort from Center 2. The method maintained stable performance under additive Gaussian noise and across different lumbar postures. Ablation studies confirmed the contributions of signal isolation, landmark-based initialization, and anatomy-aware optimization.
conclusionThis robust, high-accuracy automated method precisely reconstructs complex lumbar structures from biplanar X-rays, even for severely pathological vertebrae. Its ability to maintain accuracy under extreme movement and improve reconstruction quality in complex regions highlights its significant potential for clinical diagnosis and surgical planning.
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