Evidence map›Paper›PMID 42482563›Full record

ArticleMediators of inflammation2026

Deletion of Circadian Rhythms Gene BMAL1 Impairs the Intestinal Epithelial Barrier and Exacerbates Intestinal Inflammation by Inducing Pyroptosis.

Xin Zhou, Jie Ji, Wenhua Li, Wenxia Wu, Huanyan Zhang, Pingyu Gao, Wenjiao Ren, Guanzhao Zong, Weiliang Jiang, Rong Wan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xin ZhouDepartment of Gastroenterology, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.
Jie JiClinical Laboratory, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.
Wenhua LiDepartment of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, shsmu.edu.cn.
Wenxia WuDepartment of Gastroenterology, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.
Huanyan ZhangClinical Laboratory, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.ORCID https://orcid.org/0000-0003-0318-2762
Pingyu GaoPathology Center, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.
Wenjiao RenDepartment of Critical Care Medicine, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.
Guanzhao ZongDepartment of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, shsmu.edu.cn.
Weiliang JiangDepartment of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, shsmu.edu.cn.
Rong WanDepartment of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, shsmu.edu.cn.
Kai ZhaoDepartment of Gastroenterology, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.ORCID https://orcid.org/0000-0003-0866-6504
Yongbin MaDepartment of Central Laboratory, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.ORCID https://orcid.org/0000-0002-7287-2284
Zhanjun LuDepartment of Gastroenterology, Jintan Hospital, Jiangsu University, Changzhou, Jiangsu Province, China, ujs.edu.cn.ORCID https://orcid.org/0000-0001-6881-5810

Funding

Natural Science Foundation of Jiading District Science and Technology Commission JDKW-2023-0019Science and Technology Plan (Apply Basic Research) of Changzhou Science and Technology Bureau CJ20230003Science and Technology Project of Jiading Hospital, Shanghai General Hospital 202137A
6 · The paper itself

Abstract

The circadian clock plays a crucial role in the pathogenesis of various inflammatory and autoimmune diseases, including ulcerative colitis (UC). Deletion of the core transcription factor BMAL1 exacerbated the severity of colitis. However, the underlying molecular mechanisms of BMAL1 in UC remain unclear. We found that BMAL1 was downregulated in UC tissues and in LPS-induced MODE-K cells, whereas CXCL1 was highly expressed. Overexpression of BMAL1 reduced LPS-induced pyroptosis in MODE-K cells and restoring the expression of ZO-1, Claudin-1, and Occludin, thereby improving intestinal epithelial barrier function. Mechanistically, BMAL1 can negatively regulate the CXCL1 expression by inhibiting the activity of its promoter. Additionally, proteomics analysis identified MEF2A as a downstream protein of BMAL1. The protective effect of BMAL1 on MODE-K cells was achieved through direct negative regulation of CXCL1 or indirect negative regulation of MEF2A expression. Thus, BMAL1 plays a protective role in maintaining the integrity of the intestinal epithelial barrier and represents a potential therapeutic target for UC treatment.

Indexed as

ARNTL Transcription FactorsCircadian RhythmInflammationIntestinal MucosaPyroptosisAnimalsChemokine CXCL1Colitis, UlcerativeHumansIntestinal Barrier FunctionLipopolysaccharidesMaleMiceMice, Inbred C57BLARNTL Transcription FactorsBmal1 protein, mouseChemokine CXCL1LipopolysaccharidesBMAL1circadian rhythmsintestinal epithelial barrierpyroptosisulcerative colitis

Identifiers

PMID42482563
PMCPMC13389442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.