Evidence map›Paper›PMID 42482503›Full record

ArticleJournal of gastroenterology and hepatology2026

Differences in the Gastric Microbiotas of Neighboring Populations With Divergent Risks of Gastric Cancer.

Juan Camilo Caguazango, Karla Vinasco, Isidora Simovic, Yomaira Yépez Caicedo, Marino Coral Bedoya, Nadeem O Kaakoush, Natalia Castaño-Rodríguez

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Article in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Juan Camilo CaguazangoSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-6717-617X
Karla VinascoSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0003-4925-4434
Isidora SimovicSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0009-0002-9150-1910
Yomaira Yépez CaicedoCentro de Enfermedades Digestivas y Nutricionales CIEDYN, Pasto, Colombia.ORCID https://orcid.org/0000-0002-1828-6532
Marino Coral BedoyaCentro de Enfermedades Digestivas y Nutricionales CIEDYN, Pasto, Colombia.ORCID https://orcid.org/0000-0002-1989-0045
Nadeem O KaakoushSchool of Biomedical Sciences, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0003-4017-1077
Natalia Castaño-RodríguezSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0001-8819-8872

Funding

Australian Government Research Training ProgramCancer Australia 2012944CeiBA FoundationNHMRC APP 2033415Pancare FoundationTour de Cure RSP-525-FY2023UNSW
6 · The paper itself

Abstract

backgroundAlthough Helicobacter pylori plays a central role in gastric cancer (GC), other microorganisms involved in gastric dysbiosis may also impact carcinogenesis. We aimed to characterize gastric dysbiosis and its role in the transition from non-atrophic gastritis (NAG) to gastric premalignant lesions (GPLs) in two populations from Nariño, Colombia, with distinct GC risks: low-risk Afro-Colombians from Barbacoas and high-risk Amerindian-Mestizos from Cumbal.

methodsGastric biopsies from 200 individuals were analyzed using 16S rRNA gene sequencing. Microbial diversity and composition were assessed based on relevant clinical and sociodemographic characteristics.

resultsH. pylori infection was more prevalent in Barbacoas (83.8%) than Cumbal (70.5%), alongside higher rates of obesity (p < 0.001), alcohol intake (p : 0.07), and smoking (p : 0.02), but less severe OLGIM stages (p : 0.04). In Barbacoas, alpha diversity remained stable, whereas in Cumbal, richness significantly increased in GPL (p < 0.001). Beta diversity showed significant microbial composition differences between municipalities (p < 0.001). In Barbacoas, taxa such as Prevotella, Haemophilus, and Veillonella were dominant, whereas lactic acid bacteria such as Streptococcus were predominant in Cumbal. Barbacoas showed stable gastric microbiota composition across histological stages, whereas Cumbal exhibited enrichment of Gemella, Leptotrichia, and Prevotella in GPL.

conclusionThe Streptococcus-driven dysbiosis in Cumbal may help identify microbial biomarkers for GC progression, particularly other oral pathobionts.

Indexed as

DysbiosisGastrointestinal MicrobiomePrecancerous ConditionsStomach NeoplasmsAdultAgedColombiaFemaleGastritisHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedRiskRisk FactorsRNA, Ribosomal, 16Sgastric dysbiosisgastric premalignant lesionsHelicobacter pylorilactateoral pathobiont

Identifiers

PMID42482503
PMCPMC13534255

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