ArticleMedical physics2026
Experimental determination of PET modulation transfer functions incorporating positron range effects using an oversampled cylindrical source.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSpatial resolution is a fundamental performance parameter of positron emission tomography (PET) systems and is commonly assessed using standardized point-source-in-air procedures. While this configuration minimizes scattering and attenuation effects, it does not account for positron transport in tissue-equivalent media, whose contribution may become increasingly relevant as PET system resolution improves. PURPOSE: To develop and validate a direct experimental methodology for PET spatial resolution assessment that incorporates positron-range effects without relying on Monte Carlo simulations or parametric modeling of the system response.
methodsA modular polymethyl methacrylate (PMMA) phantom containing a thin linear radioactive source (
resultsThe oversampling strategy yielded very small statistical uncertainties in both PSF and MTF estimates. Measurements performed on two PET/CT systems of different technological generations showed negligible differences between
conclusionsThe proposed methodology provides a statistically efficient framework for experimental PET spatial-resolution characterization under realistic conditions. It enables quantitative assessment of positron-range effects and complements standardized resolution measurements, particularly in modern high-resolution PET systems.
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