Evidence map›Paper›PMID 42482429›Full record

ArticleMedical physics2026

Characterization and calibration of the iQID digital autoradiography system for direct quantitative imaging of beta-emitters in tissue samples.

Ohyun Kwon, Sean P Jollota, Adedamola O Adeniyi, Justin J Jeffery, Joseph B Schulz, Lauren E Wehner, Malick Bio Idrissou, Eduardo Aluicio-Sarduy, Brian W Miller, Denis E Bergeron and 3 more

Abstract read
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In one paragraph

Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ohyun KwonDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sean P JollotaDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Adedamola O AdeniyiDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Justin J JefferyDepartment of Human Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joseph B SchulzDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Lauren E WehnerDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Malick Bio IdrissouDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Eduardo Aluicio-SarduyDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Brian W MillerDepartments of Radiation Oncology and Medical Imaging, The University of Arizona, Tucson, Arizona, USA.
Denis E BergeronNational Institute of Standards and Technology, Gaithersburg, MD, USA.
Reinier HernandezDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Larry A DeWerdDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Bryan P BednarzDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIM, KYUNGMANN · 2020 to 2024
$12.5M
NCI NIH HHS P01 CA250972NCI NIH HHS P01CA250972NIH HHS
6 · The paper itself

Abstract

backgroundAutoradiography provides microscale mapping of radionuclide distributions, offering a promising approach to complement nuclear medicine imaging for small-scale radiopharmaceutical therapy (RPT) research. However, while quantitative protocols for α-emitters are well-established, comparable methods for β-emitters, such as the widely used theranostic radionuclide PURPOSE: The objective of this study was to characterize and calibrate the ionizing-radiation Quantum Imaging Detector (iQID) digital autoradiography system specifically for

methodsThe iQID system response was evaluated for key performance metrics, including spatial resolution, detection efficiency, background and minimum detectable activity, and depth dependence. Experimental characterization data were compared with Geant4 Monte Carlo simulations to verify the accuracy of radiation transport modeling. To establish a linearity profile, count rates were measured across an activity range of 0-300 Bq. Finally, cross-modality benchmarking was performed using a custom stacked multi-layer virtual water phantom to directly compare iQID performance with a calibrated preclinical µSPECT/CT system in a realistic measurement scenario.

resultsThe iQID system exhibited a high linear response (R

conclusionThis study establishes a validated framework for quantitative

Indexed as

AutoradiographyBeta ParticlesAnimalsCalibrationImage Processing, Computer-AssistedLutetiumMonte Carlo MethodRadioisotopesLutetiumLutetium-177Radioisotopesdigital autoradiographyradiopharmaceutical therapysmall‐scale imaging

Identifiers

PMID42482429
PMCPMC13389343

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.