ArticleMedical physics2026
Performance of detector modules designed for the NeuroSphere brain PET system.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Human Dynamic NeuroChemical Connectome (HDNCC) scanner integrates a high spatio-temporal resolution dedicated brain PET insert (NeuroSphere PET) with a commercial 7-T MRI to enable studies of neurochemical dynamics simultaneously with functional MRI on comparable timescales. PURPOSE: The NeuroSphere will achieve unprecedented sensitivity with a spherical geometry and novel detectors, which must provide time-of-flight (TOF) and depth-of-interaction (DOI) encoding without compromising crystal separation or energy resolution. We aim to develop a novel PET module for high-resolution PET/MR applications with TOF and DOI capability.
methodsThe NeuroSphere PET detector is a 10 × 10 array of 26.0-mm LSO crystals with 1.6-mm pitch coupled to a 4 × 4 SiPM array with 4-mm pitch, and a top light guide that provides DOI encoding via light sharing. Time-to-digital converter (TDC) performance and nonlinearity correction methods were evaluated with a pulsed laser. Crystal separation, energy resolution, and DOI resolution were evaluated, including a DOI-based energy correction. The ASIC readout parameters were configured and timing corrections were implemented to optimize coincidence timing resolution (CTR), including a DOI-based timing correction.
resultsThe TDC achieved 55-ps CTR between laser pulses after implementing nonlinearity correction, an improvement to the factory correction. The PET detector had good crystal identification with a peak-to-valley ratio of 11.43
conclusionsThis work has shown the capability of the NeuroSphere PET module to provide energy resolution, DOI encoding, and TOF PET competitive with other dedicated brain PET/MR systems. The CTR of
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