Evidence map›Paper›PMID 42482411›Full record

ArticleMedical physics2026

Development of an adjustable dynamic phantom for testing deviceless motion correction algorithm in PET.

Christian Kühnel, Tabea Nikola Schmidt, Leonie Schreiber, Holger Ginter, Michael Händel, Martin Freesmeyer, Falk Gühne

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Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Christian KühnelClinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany.
Tabea Nikola SchmidtClinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany.
Leonie SchreiberClinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany.
Holger GinterCentral Research Facilities, University Hospital Jena, Jena, Thuringia, Deutschland.
Michael HändelCentral Research Facilities, University Hospital Jena, Jena, Thuringia, Deutschland.
Martin FreesmeyerClinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany.
Falk GühneClinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory motion during PET Imaging leads to blurring, volumetric overestimation, and reduced quantitative accuracy. Deviceless motion correction algorithms (MCA) such as OncoFreeze (OF) by Siemens Healthineers (Forchheim, Germany) extract respiratory waveforms from list-mode data but require validation that cannot be obtained in vivo. PURPOSE: To develop and validate an adjustable dynamic phantom with fillable spheres for quantitative assessment of deviceless PET motion correction.

methodsA microprocessor-controlled two-axis phantom was constructed to generate linear craniocaudal (cc), ventrodorsal (vd), and diagonal (diag) motion with amplitudes of 0-40 mm and frequencies of 10-40 min

resultsWithout correction, motion produced substantial overestimation of apparent volume: +15%-55% (4 mL), +81%-166% (1 mL) and +276%-509% (0.25 mL), depending on trajectory and IC

conclusionsThe phantom provides a reproducible ground-truth framework for evaluating deviceless PET motion correction. MCA reduces motion-induced blurring and volumetric inflation, though correction remains size- and direction-dependent. The system enables systematic benchmarking and further optimization of motion-correction algorithms.

Indexed as

AlgorithmsImage Processing, Computer-AssistedPhantoms, ImagingPositron-Emission TomographyMovementPolymethyl MethacrylatePolymethyl Methacrylate

Identifiers

PMID42482411
PMCPMC13389335

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