ArticleMedical physics2026
Radiobiology studies of gold nanoparticle-enhanced radiosensitization in proton therapy.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrating Gold Nanoparticles with Brachytherapy: In Vitro Insights into Radiosensitization in Cervical Cancer.Cancers · 2026Article
- Radiobiology studies of gold nanoparticle-enhanced radiosensitization in proton therapy.Medical physics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundApproximately 50 PURPOSE: This work investigates the radiosensitizing effect of gold nanoparticles under proton irradiation and optimizes the irradiation setup to enable more efficient and reproducible future experiments.
methodsHeLa cells were used as the biological model for the radiobiological experiments. Irradiation conditions were optimized by incorporating a Mylar film into the culture plates to maintain a minimal medium volume and ensure rapid post-irradiation coverage. Cells with and without AuNPs were irradiated with 12.6 MeV proton beams. Radiosensitivity was assessed using clonogenic survival assays, and the radiosensitizing effect, together with its associated uncertainty, was quantified. DNA damage analysis was also performed to corroborate the observed effects and explore underlying mechanisms.
resultsThe radiobiology experiments confirmed and quantified a significant radiosensitizing effect of gold nanoparticles (AuNPs) on HeLa cells at doses from 4 Gy, with Sensitization Enhancement Ratio (SER) values of 1.53
conclusionThe radiobiology experiments presented quantitatively confirm that both 20 and 50 nm diameter AuNPs enhance the radiosensitivity of HeLa cells under proton irradiation. The radiosensitizing effect increases with dose, indicating a dose-dependent response, while no significant differences were observed between nanoparticle sizes. Consistent trends of increased DNA double-strand breaks further support the observed radiosensitization. Evidence from oxidative stress assays suggests that AuNPs may enhance ROS production under oxidative conditions, potentially contributing to the observed radiosensitization and DNA damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.