Evidence map›Paper›PMID 42482345›Full record

ReviewMicrobial biotechnology2026

Symbiont-Mediated Detoxification of Xenobiotics in Honey Bees.

Yao Liu, Esther du Rand, Christian Pirk, Huoqing Zheng

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yao LiuCollege of Animal Sciences, Zhejiang University, Hangzhou, China.
Esther du RandSocial Insects Research Group, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa.
Christian PirkSocial Insects Research Group, Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa.ORCID https://orcid.org/0000-0001-6821-7044
Huoqing ZhengCollege of Animal Sciences, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0001-8499-0694

Funding

China Agriculture Research System of MOF and MARA CARS-44National Natural Science Foundation of China 32072798National Research Foundation of South Africa
6 · The paper itself

Abstract

The active foraging behaviour of honey bees frequently exposes them to various xenobiotics. Honey bees rely primarily on endogenous enzymatic detoxification systems to metabolise these compounds; however, this capacity is constrained by limitations in their genomic detoxification repertoire. The gut microbiota may partially compensate for this deficiency through two complementary mechanisms: directly transforming or sequestering xenobiotics, and modulating host detoxification pathways. We therefore propose that the gut microbiota should be regarded as an extended detoxification organ in honey bees. This perspective also points to a microbial biotechnology agenda for pollinator protection, including precision probiotics, microbiome-informed breeding and engineered symbionts. Viewing detoxification as a holobiont trait provides a more comprehensive framework for understanding bee resilience and for developing microbiome-based interventions under real-world chemical stress.

Indexed as

Gastrointestinal MicrobiomeSymbiosisXenobioticsAnimalsBeesInactivation, MetabolicXenobioticsApisdetoxificationengineered symbiontsgut microbiotaprobioticsxenobiotics

Identifiers

PMID42482345
PMCPMC13389231

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.