Evidence map›Paper›PMID 42482272›Full record

ArticleAmerican journal of industrial medicine2026

Posttraumatic Stress Symptom Heterogeneity in World Trade Center Responders: Relations to Maladaptive Personality Traits.

Shely Khaikin, Nick Galef, Jonathan DePierro, Robert Pietrzak, Adriana Feder, Sandra Lowe

Abstract read
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Article in American journal of industrial medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shely KhaikinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0009-0002-2803-9735
Nick GalefPrivate Practice, New York, New York, USA.
Jonathan DePierroDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0002-6883-5026
Robert PietrzakDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Adriana FederDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0003-2931-310X
Sandra LoweDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0001-6456-5180

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
NCATS NIH HHS UL1 TR004419
6 · The paper itself

Abstract

backgroundThere has been growing interest in symptom heterogeneity in posttraumatic stress disorder (PTSD), yet examinations of personality variation across symptom typologies have been largely limited to veteran samples.

methodsThe present study expands this literature by examining self-reported PTSD symptoms (PTSD Checklist for DSM-IV) and potentially maladaptive personality traits (Millon Clinical Multiaxial Inventory-III) in 516 treatment-seeking World Trade Center (WTC) rescue, recovery, and cleanup workers (mean age = 51.1; 75% male).

resultsLatent class analysis identified five distinct PTSD symptom profiles: severe (n = 216), low symptom (n = 82), threat arousal (n = 73), mild numbing-hyperarousal (n = 71), and avoidance-numbing-hyperarousal (n = 68). PTSD symptom heterogeneity was meaningfully associated with distinct patterns of personality scale elevations and the total number of clinical elevations observed.

conclusionsThese findings underscore the need for assessment strategies that integrate personality profiles into conceptualization of PTSD subtypes and suggest that personality-informed approaches may enhance treatment engagement or outcomes in populations with disaster-related occupational trauma exposure.

Indexed as

Emergency RespondersOccupational DiseasesPersonalitySeptember 11 Terrorist AttacksStress Disorders, Post-TraumaticAdultFemaleHumansLatent Class AnalysisMaleMiddle Aged9/11first responderspersonalityPTSDsymptom heterogeneity

Identifiers

PMID42482272
PMCPMC13528589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.